Thermo Fisher Scientific CtIP Polyclonal Antibody
Human CtIP 단백질을 표적으로 하는 Rabbit Polyclonal Antibody로, WB 및 IP에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공. BRCA1과의 상호작용 연구 및 DNA 손상 반응 관련 연구에 적합.
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Thermo Fisher Scientific CtIP Polyclonal Antibody
Applications
- Western Blot (WB): Assay-dependent
- Immunoprecipitation (IP): 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 525 and 575 of human CtBP Interacting Protein (Retinoblastoma Binding Protein 8) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
CtIP is a 125 kD protein originally identified as interacting with transcription repressor CtBP through the PLDLS motif, suggesting a role in transcription regulation.
It also interacts with BRCA1 protein via the C-terminal BRCT domains, indicating a potential tumor suppressor function.
This CtIP–BRCA1 interaction can be disrupted by DNA-damaging agents such as UV or gamma irradiation.
Li et al. (Nature 406, 210–215, 2000) demonstrated that ATM phosphorylates CtIP at serine residues 664 and 745, and mutations at these sites prevent BRCA1 dissociation from CtIP, resulting in persistent repression of BRCA1-dependent GADD45 induction upon ionizing radiation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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