Thermo Fisher Scientific CRM1 Polyclonal Antibody

Applications

• Western Blot (WB): Assay-dependent
• Immunoprecipitation (IP): 2–5 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Exportin-1 (XPO1) mediates the nuclear export of cellular proteins bearing a leucine-rich nuclear export signal (NES) and RNAs. In the nucleus, in association with RANBP3, XPO1 binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex is mediated through binding to nucleoproteins. Upon transit of a nuclear complex into the cytoplasm, disassembly of the complex and hydrolysis of Ran-GTP to Ran-GDP cause release of the cargo from the export receptor. The directionality of nuclear export is conferred by the asymmetric distribution of GTP and GDP bound forms of Ran between the cytoplasm and nucleus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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