Thermo Fisher Scientific Phospho-IFNAR1 (Ser535, Ser539) Polyclonal Antibody
Human IFNAR1 단백질의 Ser535 및 Ser539 인산화 부위를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, 다양한 종에서 반응 예측됨. Affinity chromatography로 정제된 액상 시약으로, -20°C에서 보관.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539 of human IFNAR1 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2264542 |
Product Specific Information
This antibody is predicted to react with bovine, canine, mouse, non-human primate, and sheep based on 100% sequence homology.
It is specific for IFNAR1 protein phosphorylated at Ser535,539 in Western blots of human brain extracts.
Target Information
Interferons are widely used therapeutic agents because of their anti-tumor and antiviral effects, and because of their modulatory effects on the immune system (Biron, 2001; Kirkwood, 2002).
These cytokines produce their effects by binding to the Type 1 Interferon Receptor (IFNAR1).
Down-regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling.
This down-regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in IFNAR1 (Kumar et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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