Thermo Fisher Scientific StAR (Steroidogenic Acute Regulator) Monoclonal Antibody (STAR, 2140)
인간 StAR 단백질을 인식하는 마우스 단클론 항체입니다. 면역조직화학(IHC) 및 펩타이드 어레이에 사용 가능합니다. 단백질 A/G로 정제된 비결합형 액상 항체로, PBS(pH 7.4)에 보존제가 포함되어 있지 않습니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- 6770-MSM3-P1ABX
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STAR, 2140 |
| Immunogen | Recombinant fragment (around aa 39–108) of human STAR protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Steroidogenic acute regulatory protein (StAR) plays a key role in cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane. The 37 kDa precursor is cleaved to generate an active 28 kDa protein that facilitates cholesterol metabolism into pregnenolone. StAR is expressed in mitochondria of steroid-producing adrenal and gonadal tissues. Abnormal expression of the StAR gene is associated with autosomal Lipoid Congenital Adrenal Hyperplasia (LCAH), leading to defects in pregnenolone and cortisol synthesis. The mechanism of cholesterol binding to StAR remains under investigation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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