Thermo Fisher Scientific StAR (Steroidogenic Acute Regulator) Monoclonal Antibody (STAR, 2140)
Thermo Fisher Scientific의 StAR 단일클론 항체는 인간 StAR 단백질(aa 39-108)을 인식하며 면역조직화학(IHC) 및 펩타이드 어레이에 적합합니다. 단백질 A/G로 정제된 액상 형태로 제공되며, 4°C에서 보관합니다. 스테로이드 생성 관련 연구에 유용한 고특이성 항체입니다.
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- 6770-MSM3-P0
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | STAR, 2140 |
| Immunogen | Recombinant fragment (around aa 39–108) of human STAR protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
Steroidogenic acute regulatory protein (StAR) is essential for cholesterol transport from the cytoplasmic outer membrane to the inner mitochondrial membrane.
The 37 kDa precursor is cleaved to produce an active 28 kDa form that facilitates cholesterol metabolism into pregnenolone.
StAR is expressed in the mitochondria of steroid-producing adrenal and gonadal tissues.
Mutations or defects in StAR gene expression are associated with autosomal Lipoid Congenital Adrenal Hyperplasia (LCAH), resulting in impaired pregnenolone and cortisol synthesis.
The mechanism of cholesterol binding to StAR remains to be fully elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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