Thermo Fisher Scientific ER-beta (Estrogen Receptor beta-5) Monoclonal Antibody (PPG5/25)
ER-beta (Estrogen Receptor beta-5) 단일클론 항체로, 인간 ERβ5 단백질을 특이적으로 인식합니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 단백질 발현 연구 및 핵 수용체 기능 분석에 유용합니다. 단백질 A/G 정제, 보존제 무첨가, 액상 형태.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PPG5/25 |
| Immunogen | Tuberculin conjugated synthetic peptide (LLSHVRHARYAP), derived from the C-terminus of human Estrogen Receptor beta 5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
This monoclonal antibody specifically recognizes human estrogen receptor beta 5 (ERB5), a splice variant of the nuclear receptor hormone ER beta (ESR2), which exists in at least five isoforms (ERB1–ERB5). No cross-reactivity is observed with estrogen receptor beta 1 or 2 isoforms.
The gene encodes a member of the estrogen receptor family and the nuclear receptor transcription factor superfamily. The protein includes an N-terminal DNA-binding domain and a C-terminal ligand-binding domain, localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17β-estradiol or related ligands, the protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms can dominantly inhibit other estrogen receptor family members.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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