Thermo Fisher Scientific Nestin Polyclonal Antibody

Thermo Fisher Scientific Nestin Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P))

Tested Dilution: 1:100

Product Specifications

Product Specific Information

Heat-mediated antigen retrieval is recommended prior to staining, using a 10 mM citrate buffer (pH 6.0) for 10 minutes, followed by cooling at room temperature for 20 minutes.
After antigen retrieval, incubate samples with primary antibody for 30 minutes at room temperature.
A suggested positive control is liver hepatoma.

Target Information

Nestin is a Class VI intermediate filament abundantly produced in the developing central nervous system (CNS) and early embryonic neuroepithelial stem cells.
It is widely used as a marker for stem/progenitor cells, glioma cells, and tumor endothelial cells.
Nestin serves as a superior angiogenic marker to evaluate neovascularity of endothelial cells in tumors.
Highly specific antibodies to human Nestin help characterize progenitor cell differentiation and enhance therapeutic potential in CNS disease or injury.
Nestin expression has also been observed in pancreatic hematopoietic stem cell populations and as a novel angiogenesis marker in proliferating endothelial cells of colorectal cancer tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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