Thermo Fisher Scientific RPH3A Polyclonal Antibody
RPH3A 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot에 적합합니다. Rat에 반응하며 mouse, human 등에도 예측 반응성을 가집니다. Affinity chromatography로 정제된 액상 제품으로, -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminal region of rat RPH3A conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_617616 |
Product Specific Information
This antibody is predicted to react with mouse, human, bovine, canine, and non-human primate based on 100% sequence homology.
In Western blot, this antibody is specific for the ~82 kDa rabphilin 3A protein.
Target Information
The carboxy-terminal of rabphilin-3A consists of two C2 domains, A and B, and the amino-terminal (residues 45–170) contains a cysteine-rich region with two zinc finger motifs.
Rabphilin-3A belongs to the C-type tandem C2 protein family, which includes synaptotagmins and Doc2. It is expressed in neuroendocrine cells and co-localizes with Rab3A on synaptic vesicles and chromaffin granules.
Rabphilin-3A binds Rab3a/GTP/Mg²⁺ within amino-terminal residues 45–170 and interacts with calcium ions and phosphatidylinositol 4,5-bisphosphate-containing lipid vesicles within its C2 domains.
Rabphilin-3A acts as a positive regulator of calcium-dependent exocytosis, while Rab3a negatively regulates exocytosis. Although rabphilin-3A associates with Rab3a, they influence exocytosis independently, likely through an unknown factor recognizing the Rab3 binding domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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