Thermo Fisher Scientific Bcl-X (Apoptosis Marker) Monoclonal Antibody (BX006, 2H12)
Bcl-X 단백질을 표적하는 항체로 apoptosis 연구에 적합. Western blot 및 immunohistochemistry에 사용 가능. Human, Mouse, Pig, Rat 반응성. 단일클론 항체로 높은 특이성과 재현성 제공. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BX006, 2H12 |
| Immunogen | A synthetic peptide, aa 3–14 (Cys-QSNRELVVDFLS) of human Bcl-X protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the BCL-X gene belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.
These proteins are located at the outer mitochondrial membrane and regulate the opening of the VDAC channel, which controls mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release—key steps in apoptosis induction.
Alternative splicing produces multiple transcript variants encoding two isoforms: the longer isoform acts as an apoptotic inhibitor, while the shorter isoform acts as an apoptotic activator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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