Thermo Fisher Scientific Bcl-X (Apoptosis Marker) Monoclonal Antibody (SPM519)
Bcl-X 단백질을 표적하는 Thermo Fisher Scientific의 단클론 항체로, 세포 사멸(apoptosis) 연구용으로 적합합니다. 인간 시료에 반응하며 IHC(P), IHC(PFA) 등 다양한 면역조직화학 실험에 사용 가능합니다. 단백질 A/G로 정제된 액상 형태의 항체입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM519 |
| Immunogen | Recombinant human BCL2L1 protein fragment (around aa 1–135) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the BCL-X gene belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular processes. These proteins are located at the outer mitochondrial membrane and regulate the VDAC channel, which controls mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release — all key factors in apoptosis induction.
Alternative splicing produces multiple transcript variants encoding two isoforms:
- The longer isoform acts as an apoptotic inhibitor
- The shorter isoform acts as an apoptotic activator
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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