Thermo Fisher Scientific Bcl-X (Apoptosis Marker) Monoclonal Antibody (2H12)
Bcl-X 단백질을 표적하는 단클론 항체로, apoptosis 연구에 적합합니다. Western blot, IHC, ICC, Flow Cytometry 등 다양한 응용에 사용 가능합니다. Human, Mouse, Pig, Rat 반응성이 있으며 Protein A/G로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- 598-MSM2-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Bcl-X (Apoptosis Marker) Monoclonal Antibody (2H12)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Pig, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H12 |
| Immunogen | A synthetic peptide, aa 3–14 (Cys-QSNRELVVDFLS) of human Bcl-X protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the BCL-X gene belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities. These proteins are located at the outer mitochondrial membrane and regulate the opening of the mitochondrial channel (VDAC), which controls mitochondrial membrane potential, reactive oxygen species production, and cytochrome C release — all key steps in apoptosis.
Alternative splicing results in multiple transcript variants encoding two isoforms: the longer isoform inhibits apoptosis, while the shorter isoform promotes it.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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