Thermo Fisher Scientific NSE gamma (Neuron Specific Enolase, gamma) (Neuroendocrine Marker) Monoclonal Antibody (ENO2/4507)

Applications and Tested Dilution

Product Specifications

Target Information

Neuron specific enolase (NSE, ENO1, ENO2, ENO3) is an enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis.
NSE is highly stable in biological fluids and can diffuse into extracellular media and cerebrospinal fluid (CSF) when neuronal membranes are injured.

There are three mammalian enolases: ENO1 (alpha), ENO2 (beta), and ENO3 (gamma).

• Alpha-subunit: expressed in most tissues
• Beta-subunit: expressed in muscle
• Gamma-subunit: expressed primarily in neurons and neuroendocrine cells

Co-expression of NSE and chromogranin A is common in neuroendocrine neoplasms.
Because neurons require high energy, they are rich in glycolytic enzymes such as GAPDH and NSE.

Antibodies to NSE are useful for identifying neuronal cell bodies, developing neuronal lineage, and neuroendocrine cells.
Release of NSE from damaged neurons into CSF and blood serves as a biomarker for neuronal injury and is clinically used to detect neuronal damage in disorders such as stroke, hypoxic brain damage, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis.
Elevated NSE levels are also found in plasma and certain neoplasias including pediatric neuroblastoma and small cell lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.