Thermo Fisher Scientific MBD1 Monoclonal Antibody (100B272.1)
MBD1 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단일클론 항체. Western blot, IHC, ICC, IP, ChIP 등 다양한 응용 가능. 인간 및 마우스 반응성, Protein G 정제, PBS 버퍼에 0.02% sodium azide 포함. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
| Immunoprecipitation (IP) | 1:10–1:500 |
| ChIP assay (ChIP) | 1:10–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 100B272.1 |
| Immunogen | Synthetic peptide corresponding to amino acids 391–405 (SESEDGAGSPPPYRR) of human MBD1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076606 |
Product Specific Information
- Suggested positive control: HeLa whole cell extract, HeLa cell lysate.
Target Information
Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It acts as a transcriptional repressor by binding CpG islands in promoters where DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG produced by DNA damage from methylmethanesulfonate (MMS). MBD1 recruits AFT7IP and histone methyltransferase SETDB1 for gene silencing. Isoforms 1 and 2 can also repress transcription from unmethylated promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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