Thermo Fisher Scientific Myeloperoxidase Recombinant Rabbit Monoclonal Antibody (JM10-58)
Myeloperoxidase 단백질을 인식하는 재조합 토끼 단일클론 항체로 높은 특이성과 민감도를 제공. WB, IHC, ICC/IF에 적합하며 HEK293 세포에서 발현된 IgG 형태. 일관된 로트 간 품질과 동물 유래 성분 없는 제형으로 연구용에 최적화됨.
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Thermo Fisher Scientific Myeloperoxidase Recombinant Rabbit Monoclonal Antibody (JM10-58)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM10-58 |
| Immunogen | Synthetic peptide within Human Myeloperoxidase aa 178–219 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809859 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the larger rabbit immune repertoire
Target Information
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation and is a major component of neutrophil azurophilic granules. It is produced as a single-chain precursor that is cleaved into light and heavy chains, forming a mature tetramer (2 light chains and 2 heavy chains).
MPO generates hypohalous acids essential for neutrophil microbicidal activity.
Associated diseases include Myeloperoxidase Deficiency and Familial Alzheimer’s Disease (Type 1).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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