Thermo Fisher Scientific NOTCH4 Recombinant Rabbit Monoclonal Antibody (JM101-05)
Recombinant rabbit monoclonal antibody recognizing NOTCH4. Validated for Western blot in human and mouse samples. Offers high specificity, lot-to-lot consistency, and animal origin-free formulation. Suitable for research use only.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM101-05 |
| Immunogen | Synthetic peptide within Human NOTCH4 aa 1920–1960 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809858 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
The NOTCH4 gene encodes a Type I transmembrane receptor belonging to the Notch family. These proteins possess multiple epidermal growth factor-like (EGF) repeats in the extracellular domain and various intracellular domain motifs.
Notch family members regulate cell fate decisions in development. NOTCH4 is cleaved in the trans-Golgi network and presented as a heterodimer on the cell surface. It functions as a receptor for membrane-bound ligands and may play roles in vascular, renal, and hepatic development. Some studies suggest an association with schizophrenia susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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