Thermo Fisher Scientific CD21 Monoclonal Antibody (LT21), PE
CD21 항원을 인식하는 LT21 클론의 단클론 항체로, PE 형광체로 결합되어 Flow Cytometry에 적합합니다. 사람, 소, 개, 돼지 시료에 반응하며, B 세포 및 여포 수지상세포의 CD21 발현 분석에 유용합니다. 액상 형태로 4°C 보관합니다.
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Applications
- Flow Cytometry (Flow): 20 µL/10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Dog, Human, Pig |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | LT21 |
| Immunogen | IM9 human B-lymphoblastoid cell line |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1955172 |
Available Formats
- Unconjugated (MA1-19243)
- Alexa Fluor 647 (MA5-18131)
- FITC (MA1-19753)
- Custom conjugation available upon request
Product Specific Information
This antibody reacts with an extracellular epitope of CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells, and subsets of T lymphocytes. It is not expressed on immature B cells.
Target Information
CD21 (complement receptor 2, CR2, C3D receptor, EBV receptor) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement-activating surfaces or antigens. CD21 plays important roles in:
- Uptake and retention of immune complexes
- Survival of memory B cells
- Development and maintenance of humoral responses to T-dependent antigens
CD21 also serves as a receptor for Epstein-Barr virus (EBV) and is involved in targeting prions to follicular dendritic cells, facilitating neuroinvasion after peripheral exposure. A soluble form (sCD21) retains ligand-binding ability. CD21 associates with CD19, CD81, and Leu13 to form a signal-transduction complex involved in B cell activation. Genetic variations in the CD21 gene are linked to susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternative splicing produces multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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