Thermo Fisher Scientific SSEA1 Monoclonal Antibody (MEM-158), PE

Applications

• Flow Cytometry (Flow): 20 µL per 100 µL whole blood or 10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (MA1-19094)
• APC (MA1-10106)
• Biotin (MA1-19490)
• FITC (MA1-19562)
• Request custom conjugation available

Product Specific Information

This antibody reacts with CD15, a cell membrane molecule (3-fucosyl-N-acetyllactosamine, 3-FAL) strongly expressed on the surface of granulocytes, monocytes, macrophages, and mast cells. It is also present on Langerhans cells and certain myeloid precursor cells.
This antibody does not cross-react with porcine, bovine, or sheep.

Target Information

CD15 (Lewis X, Le(x); stage specific embryonic antigen-1, SSEA-1) is a trisaccharide determinant (3-fucosyl-N-acetyllactosamine) expressed on glycolipids, glycoproteins, and proteoglycans of various cell types such as granulocytes, mast cells, monocytes, macrophages, gastric mucosa cells, nervous system cells, and tumor cells.
Variants include sialyl-Lewis X and sulphated Lewis X. Cells with high Le(x) surface expression show strong self-aggregation via calcium-dependent Le(x)-Le(x) interaction, relevant in embryo compaction and teratocarcinoma cell aggregation.
Sialyl-Le(x) and sialyl-Le(a) act as selectin ligands. CD15 expression is widely used for Hodgkin’s disease diagnosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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