Thermo Fisher Scientific CD10 Monoclonal Antibody (MEM-78), APC
인간 CD10 항원을 인식하는 Mouse IgG1 단일클론 항체로 APC 형광체가 결합되어 있습니다. Flow cytometry에 적합하며 NALM-6 세포주로부터 유래한 면역원 사용. 4°C 암조건 보관, 연구용으로만 사용.
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Thermo Fisher Scientific CD10 Monoclonal Antibody (MEM-78), APC
Applications
- Flow Cytometry (Flow)
Tested Dilution: 10 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-78 |
| Immunogen | NALM-6 human pre-B cell line |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1955019 |
Additional Formats
- Unconjugated
- FITC
- PE
- PerCP
- Request custom conjugation
Product Specific Information
This antibody reacts with an extracellular epitope of CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein.
Target Information
CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA) is a cell surface enzyme with neutral metalloendopeptidase activity that inactivates various biologically active peptides.
CD10 is expressed on lymphoblastic, Burkitt’s, and follicular germinal center lymphomas, immature B cells in adult bone marrow, and cells from patients with chronic myelocytic leukemia (CML).
It is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, and highly expressed on kidney and gut epithelial brush borders.
CD10 cleaves peptides at the amino side of hydrophobic residues and inactivates peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
It is a 100 kDa type II transmembrane glycoprotein encoded by a >45 kb gene with alternatively spliced 5′ UTR producing four mRNA transcripts.
Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie-Tooth disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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