Thermo Fisher Scientific CD10 Monoclonal Antibody (MEM-78), APC

Thermo Fisher Scientific CD10 Monoclonal Antibody (MEM-78), APC

Applications

• Flow Cytometry (Flow)

Tested Dilution: 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• FITC
• PE
• PerCP
• Request custom conjugation

Product Specific Information

This antibody reacts with an extracellular epitope of CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein.

Target Information

CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA) is a cell surface enzyme with neutral metalloendopeptidase activity that inactivates various biologically active peptides.
CD10 is expressed on lymphoblastic, Burkitt’s, and follicular germinal center lymphomas, immature B cells in adult bone marrow, and cells from patients with chronic myelocytic leukemia (CML).
It is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, and highly expressed on kidney and gut epithelial brush borders.
CD10 cleaves peptides at the amino side of hydrophobic residues and inactivates peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
It is a 100 kDa type II transmembrane glycoprotein encoded by a >45 kb gene with alternatively spliced 5′ UTR producing four mRNA transcripts.
Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie-Tooth disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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