Thermo Fisher Scientific SMC1A Monoclonal Antibody (OTI11E1), TrueMAB
SMC1A 단백질을 인식하는 Mouse IgG2b 단일클론 항체로 Western blot 및 IHC(P) 분석에 적합. 인간, 마우스, 랫트 반응성. 동결건조 형태로 제공되며, PBS 버퍼에 8% 트레할로스 포함. 염색체 구조 유지 관련 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11E1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 889–1016 of human SMC1A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play essential roles in nuclear events requiring chromosomal structural changes, including mitotic chromosome organization, DNA recombination and repair, and transcriptional repression.
SMC1 and SMC3 form a heterodimeric complex crucial for metaphase progression and sister chromatid cohesion.
Mutations in the SMC1A gene are associated with Cornelia de Lange syndrome type 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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