Thermo Fisher Scientific PD-L1 Monoclonal Antibody (OTI13G7), TrueMAB
Human PD-L1 단백질(aa 19-239)을 항원으로 한 Mouse IgG1 단클론 항체입니다. ICC/IF, Flow Cytometry, ELISA에 사용 가능하며, carrier-free 형식으로 제공됩니다. 종양 면역 회피 연구에 적합한 고품질 TrueMAB 항체입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:5,000 |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI13G7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 19–239 of human PD-L1/CD274 produced in HEK293 cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, it is recommended to add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a B7 family member that binds to the programmed death receptor 1 (PD-1).
This interaction negatively regulates T-cell receptor (TCR) signaling, reducing TCR-mediated proliferation and cytokine production.
PD-L1 expression is abundant in many murine and human cancers and can be upregulated by IFN-γ stimulation, suggesting its role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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