Thermo Fisher Scientific PGR Monoclonal Antibody (OTI20A1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors mediating the physiological effects of progesterone, which is essential for reproductive processes such as pregnancy establishment and maintenance.
PR exists as two isoforms: PR-A (94 kDa) and PR-B (120 kDa), generated by alternative translation initiation. PR-B is transcriptionally active and regulates genes for endometrial maintenance, pregnancy, and ovulation inhibition. PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
Inactive PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, the receptor undergoes conformational change, dimerizes, and binds to progesterone response elements (PRE), leading to transcriptional activation.
Null mutations in the PGR gene cause various reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.