Thermo Fisher Scientific PGR Monoclonal Antibody (OTI24A2), TrueMAB
인간 PGR 단백질(1-298 aa)에 특이적인 Mouse IgG1 단클론 항체. Western blot 검증 완료. 동결건조 형태, PBS(8% trehalose) 저장. 재구성 후 1 mg/mL 농도로 사용 가능. 연구용 시약으로 생식 관련 호르몬 수용체 연구에 적합.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI24A2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–298 of human PGR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The progesterone receptor (PR) is a nuclear receptor that mediates the effects of progesterone, a key hormone in reproductive processes such as establishment and maintenance of pregnancy.
PR exists as two isoforms: PR-A (94 kDa) and PR-B (120 kDa), generated by alternative translation initiation. PR-B is transcriptionally active, regulating genes involved in endometrial maintenance and ovulation inhibition. PR-A lacks 165 amino acids at the N-terminus, exposing an inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive form, PR associates with heat shock proteins and immunophilins. Upon progesterone binding, PR undergoes conformational changes, dimerizes, and binds to progesterone response elements (PREs) to activate gene transcription.
Mutations in the PGR gene can lead to reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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