Thermo Fisher Scientific Phospho-Tau (Ser422) Polyclonal Antibody
인간 Tau 단백질의 Ser422 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제되었으며, BSA 및 sodium azide 포함 PBS buffer에 보관. 신경퇴행성 질환 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 13 publications |
| Immunohistochemistry (IHC) | - | View 9 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 3 publications |
| Immunohistochemistry - Free Floating (IHC (Free)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | - | View 2 publications |
| ELISA | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse, Tag |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from human Tau containing Ser422; sequence conserved in mouse and rat |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS (pH 7.3) with 1 mg/mL BSA |
| Contains | 0.05% Sodium Azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533748 |
Target Information
Tau is a neuronal microtubule-associated protein predominantly located on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus interacts with neural plasma membrane components, functioning as a linker between both structures. Tau localization determines axonal polarity within neurons. Short isoforms contribute to cytoskeletal plasticity, whereas longer isoforms aid stabilization.
Hyper-phosphorylated Tau forms paired helical filaments (PHF), the main component of neurofibrillary lesions in Alzheimer’s disease (AD). Phosphorylation disrupts Tau’s microtubule binding ability, leading to destabilization and neuronal degeneration. Tau is phosphorylated by multiple kinases, including GSK-3β, PKA, CDK5, and casein kinase II. Hyper-phosphorylated Tau also appears in other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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