Thermo Fisher Scientific Phospho-Tau (Ser409) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures. Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body.

Short isoforms of Tau contribute to cytoskeletal plasticity, while longer isoforms are involved in stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), which form neurofibrillary tangles in Alzheimer’s disease (AD). Hyper-phosphorylation disrupts Tau’s microtubule-binding function, leading to microtubule destabilization and neuronal degeneration in AD brains.

Numerous kinases such as GSK-3β, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5), and casein kinase II phosphorylate Tau. Hyper-phosphorylated Tau is also associated with other neurodegenerative disorders including Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.