Thermo Fisher Scientific Phospho-Tau (Ser396) Polyclonal Antibody
Tau 단백질 Ser396 인산화 부위를 인식하는 rabbit polyclonal antibody로, 인간·마우스·랫트 반응성 확인됨. Western blot, IHC 등 다양한 응용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. 연구용으로 알츠하이머병 등 신경퇴행성 질환 연구에 적합.
- 카탈로그번호
- 44752G
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-Tau (Ser396) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | 64 publications |
| Immunohistochemistry (IHC) | - | 11 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:500 | - |
| Immunohistochemistry - Free Floating (IHC (Free)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | Assay-dependent | 3 publications |
| ELISA | - | 2 publications |
| Neutralization (Neu) | - | 1 publication |
| Inhibition Assays (IA) | - | 1 publication |
| Miscellaneous PubMed (Misc) | - | 3 publications |
Product Specifications
| Category | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Bovine, Human, Mouse, Rat, Tag |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from human Tau containing serine 396. Sequence conserved in mouse, rat, rhesus monkey, baboon, cow, and goat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533745 |
Product Specific Information
This antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the phosphorylation site to remove reactivity with non-phosphorylated Tau. The final antibody is purified by affinity chromatography using a Tau-derived peptide phosphorylated at serine 396.
Target Information
Tau is a neuronal microtubule-associated protein primarily localized in axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, acting as a linker between them. Tau localization defines axonal polarity and contributes to cytoskeletal plasticity and stability. Hyper-phosphorylated Tau forms paired helical filaments (PHF), a major component of neurofibrillary tangles in Alzheimer’s disease (AD) brains. This modification impairs Tau’s microtubule binding, leading to neuronal degeneration. Phosphorylation is mediated by kinases including GSK-3β, PKA, cdk5, and casein kinase II. Abnormal Tau phosphorylation is implicated in AD, Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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