Thermo Fisher Scientific DNMT3B Recombinant Rabbit Monoclonal Antibody (7Y9S2)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:

MKGDTRHLNG EEDAGGREDS ILVNGACSDQ SSDSPPILEA IRTPEIRGRR SSSRLSKREV SSLLSYTQDL TGDGDGEDGD GSDTPVMPKL FRETRTRSES PAVRTRNNNS VSSRERHRPS PRSTRGRQGR NHVDESPVEF PATRSLRRRA TASAGTPWPS PPSSYLTIDL TDDTEDTHGT PQSSSTPYAR LAQDSQQGGM ESPQVEADSG DGDSSEYQDG KEFGIGDLVW GKIKGFSWWP AMVVSWKATS KRQAMSGMRW VQWFGDGKFS EVSADKLVAL GLFSQHFNLA TFNKLVSYRK AMYHALEKAR VRAGKTFPSS PGDSLEDQLK PMLEWAHGGF KPTGIEGLKP NNTQPVVNKS KVRRAGSRKL ESRKYENKTR RRTADDSATS DYCPAPKRLK TNCYNNGKDR

Target Information

CpG methylation is an epigenetic modification important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development.
This gene encodes a DNA methyltransferase that functions in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus, and its expression is developmentally regulated.
Mutations in this gene cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described; the full-length sequences of variants 4 and 5 have not been determined.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.