Thermo Fisher Scientific Phospho-Cyclin B1 (Ser126) Polyclonal Antibody
Cyclin B1의 Ser126 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 적용 가능. 인간 단백질에 반응하며, 고순도(>95%)로 정제됨. 세포주기 G2/M 조절 및 암 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Cyclin B1 around the phosphorylation site of Serine 126 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553675 |
Product Specific Information
- Detects endogenous Cyclin B1 protein at ~60 kDa.
- Purity >95% by SDS-PAGE.
Target Information
Cyclins bind to and regulate Cyclin-dependent protein kinases (CDKs).
Cyclin B1 (CCNB1) is a regulatory protein essential for mitosis and cell cycle control at the G2/M transition.
It forms a complex with p34 (cdc2) to create the maturation-promoting factor (MPF).
Two transcripts are known: a constitutive form and a cell cycle-regulated form expressed mainly during G2/M phase.
Cyclin B1 accumulates during G2 phase and is degraded at mitosis end via APC-dependent destruction, necessary for cell cycle progression.
Overexpression of Cyclin B1 is linked to several cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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