Thermo Fisher Scientific Phospho-IRS1 (Ser1101) Polyclonal Antibody
인간 IRS-1 단백질의 Ser1101 인산화 부위를 인식하는 폴리클로날 항체. Western blot 및 IHC(파라핀)에서 사용 가능. 고순도(>95%) 항원 친화 크로마토그래피 정제. 액상 형태로 제공되며 장기 보관 시 -20°C 권장.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-IRS1 (Ser1101) Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human IRS-1 around the phosphorylation site of Serine 1101 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553678 |
Product Specific Information
This antibody detects endogenous IRS-1 protein at molecular weights of approximately 132 and 180 kDa.
Purity is >95% by SDS-PAGE.
Target Information
IRS-1 is a major substrate of the insulin receptor and is phosphorylated in response to stimulation by insulin, IGF-1, and IL-4. It undergoes serine, threonine, and tyrosine phosphorylation in various tissues. Casein kinase II mediates part of the insulin-stimulated phosphorylation of IRS-1, with Thr502 and Ser99 identified as key sites. IRS-1 also contains three potential 14-3-3 binding sites (Ser270, Ser374, Ser641), with Ser270 located in the phosphotyrosine-binding domain responsible for interaction with the insulin receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.