Thermo Fisher Scientific SLC25A13 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
KVALTKRADP AELRTIFLKY ASIEKNGEFF MSPNDFVTRY LNIFGESQPN PKTVELLSGV VDQTKDGLIS

Antigen sequence identity:

• Mouse: 96%
• Rat: 96%

Target Information

Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2, or CTLN2, is a 675 amino acid multi-pass membrane protein localized to the inner mitochondrial membrane. It is expressed in liver, pancreas, kidney, brain, heart, and placenta. Citrin functions as a calcium-dependent glutamate and aspartate carrier involved in the urea cycle.

Citrin belongs to the mitochondrial carrier family and contains three Solcar repeats and four EF-hand domains for calcium binding.
Mutations in the SLC25A13 gene are associated with citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD).

• CTLN2: Autosomal recessive disorder causing neuropsychiatric symptoms such as memory loss, seizures, and coma.
• NICCD: Non-lethal infant disorder characterized by low birth weight, reduced bile flow, growth retardation, and hepatic fibrosis.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.