Thermo Fisher Scientific SLC25A13 Polyclonal Antibody
SLC25A13 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot, IHC, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 인간 시료에 반응하며 연구용으로만 사용 가능합니다.
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- PA553887
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SLC25A13 (Product #RP-92588) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647401 |
Product Specific Information
Immunogen sequence:
KVALTKRADP AELRTIFLKY ASIEKNGEFF MSPNDFVTRY LNIFGESQPN PKTVELLSGV VDQTKDGLIS
Antigen sequence identity:
- Mouse: 96%
- Rat: 96%
Target Information
Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2, or CTLN2, is a 675 amino acid multi-pass membrane protein localized to the inner mitochondrial membrane. It is expressed in liver, pancreas, kidney, brain, heart, and placenta. Citrin functions as a calcium-dependent glutamate and aspartate carrier involved in the urea cycle.
Citrin belongs to the mitochondrial carrier family and contains three Solcar repeats and four EF-hand domains for calcium binding.
Mutations in the SLC25A13 gene are associated with citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD).
- CTLN2: Autosomal recessive disorder causing neuropsychiatric symptoms such as memory loss, seizures, and coma.
- NICCD: Non-lethal infant disorder characterized by low birth weight, reduced bile flow, growth retardation, and hepatic fibrosis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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