Thermo Fisher Scientific HHATL Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Immunohistochemistry (IHC)

2.5 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A 19 amino acid synthetic peptide near the amino terminus of human HHATL if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HHATL,uniProtId:Q9HCP6-1,ncbiNodeId:9606,antigenRange:1,antigenLength:504,antigenImageFileName:PA5-34355_HHATL_Q9HCP6-1_Rabbit.svg,antigenImageFileNamePDP:PA5-34355_HHATL_Q9HCP6-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2551707

Product Specific Information

A suggested positive control is NIH-3T3 cell lysate.

PA5-34355 can be used with blocking peptide PEP-1398.

Target Information

HHATL (Hedgehog Acyltransferase-Like) is a gene that codes for a protein involved in the regulation of Hedgehog signaling pathways. HHATL is located on chromosome 7q36.3. Structurally, the protein encoded by this gene is characterized by an acyltransferase domain, which plays a crucial role in the N-palmitoylation of the Sonic Hedgehog (Shh) protein, a process essential for its proper signaling activity and distribution. Functionally, HHATL has been implicated in various biological processes, including amelioration of endoplasmic reticulum stress through autophagy. The gene is expressed in several tissues, with notable high expression in the heart, suggesting a potential role in cardiac development and function. Dysfunction in HHATL could lead to anomalies in Hedgehog signaling, impacting various developmental and cellular processes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.