Thermo Fisher Scientific Phospho-iNOS (Tyr151) Polyclonal Antibody
Phospho-iNOS (Tyr151) 항체로 인산화된 iNOS의 내인성 수준을 검출. Western blot 및 IHC(P) 적용 가능. Human, Mouse, Rat 반응성. 고순도 Rabbit Polyclonal 형식으로 연구용에 적합.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-iNOS (Tyr151) Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NOS2 (Accession P35228), corresponding to amino acid residues around phosphorylated Tyr151 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818303 |
Product Specific Information
Antibody detects endogenous levels of iNOS only when phosphorylated at Tyrosine 151.
Target Information
iNOS (Inducible Nitric Oxide Synthase, NOS) is an inorganic, gaseous free radical messenger involved in vasorelaxation, neurotransmission, and cytotoxicity. NO production is mediated by NOS family members.
iNOS is expressed in liver and induced by lipopolysaccharide and cytokines. It catalyzes oxidation of L-arginine to produce L-citrulline and NO.
Three isoforms exist: neuronal NOS (nNOS, type I), endothelial NOS (eNOS, type III), and inducible NOS (iNOS, type II).
iNOS is found in macrophages, hepatocytes, synoviocytes, and smooth muscle cells. Cytokines such as IFN-γ, TNF, IL-1/2, and LPS increase iNOS mRNA and activity.
Protein kinase C activation also enhances iNOS activity. After induction, iNOS shows delayed but sustained NO production.
Three related pseudogenes are located in the Smith-Magenis syndrome region on chromosome 17.
Diseases associated with iNOS dysfunction include achalasia and impotence.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-99370_iNOS_P35228-1_Rabbit.svg)
(이미지 파일명: PA5-99370_iNOS_P35228-1_Rabbit_PDP.jpeg)
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.