Thermo Fisher Scientific EDN3 Polyclonal Antibody
Human EDN3 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot 및 ELISA에 적합. Affinity Chromatography로 정제된 액상 형태이며, 안정적인 PBS/glycerol buffer에 보관. Neural crest 관련 질환 연구에 활용 가능.
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- PA5109675
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 17–187 of human EDN3 (NP_996917.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.88 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2855086 |
Product Specific Information
Immunogen sequence:
AGFVPCSQSG DAGRRGVSQA PTAARSEGDC EETVAGPGEE TVAGPGEGTV APTALQGPSP GSPGQEQAAE GAPEHHRSRR CTCFTYKDKE CVYYCHLDII WINTPEQTVP YGLSNYRGSF RGKRSAGPLP GNLQLSHRPH LRCACVGRYD KACLHFCTQT LDVSSNSRTA E
Target Information
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in various biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein, acting as a ligand for endothelin receptor type B (EDNRB). This interaction is essential for the development of neural crest-derived cell lineages such as melanocytes and enteric neurons. Mutations in this gene and EDNRB are associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), congenital disorders involving neural crest-derived cells. Four alternatively spliced transcript variants encoding three distinct isoforms have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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