Thermo Fisher Scientific CD27 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV KDCDQHRKAA QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA NAECACRNGW QCRDKECTEC DPLPNPSLTA RSSQALSPHP QPTHLPYVSE MLEARTAGHM QTLADFRQLP ARTLSTHWPP QRSLCSSDFI RILVIFSGMF LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCRYSCPREE EGSTIPIQED YRKPEPACSP

Target Information

CD27 is a 50 kDa member of the tumor necrosis factor (TNF) receptor superfamily that includes CD40 and CD30. Members of this family regulate cell proliferation and death.
CD27 and its ligand CD70 are predominantly expressed in lymphocytes. High CD27 expression depends on proper antigen receptor ligation, while CD70 expression requires co-stimulatory or pro-inflammatory signals.
CD27 is expressed as a disulfide-linked homodimer on mature thymocytes, peripheral blood T cells, and a subpopulation of B cells. Activation of T cells via the TCR-CD3 complex upregulates CD27 expression and releases its soluble form (sCD27), a 28–32 kDa protein detectable in plasma, urine, or spinal fluid.
Soluble CD27 serves as a prognostic marker for acute and chronic B-cell malignancies. RgpA, a cysteine proteinase, degrades CD27 and counteracts T-cell activation mediated by CD27-CD70 interaction. CD27-binding protein (SIVA), a proapoptotic protein, binds to CD27 and contributes to apoptosis induced by this receptor.
Diseases associated with CD27 dysfunction include Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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