Thermo Fisher Scientific CD28 Monoclonal Antibody (1H3)
CD28 단백질을 표적으로 하는 Mouse IgG1 단클론 항체로, 인간 시료에 반응합니다. Western blot과 ELISA에 사용 가능하며, PBS 기반 용액 형태로 제공됩니다. 세포 활성화 연구 및 T세포 공자극 신호 분석에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1H3 |
| Immunogen | CD28 (NP_006130.1, 18–152 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GNKILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKP
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein.
It is a cell adhesion molecule of the immunoglobulin superfamily constitutively expressed on most peripheral blood T lymphocytes.
CD28 provides a critical T cell costimulatory signal by binding CD80 and CD86 on antigen-presenting cells, preventing T cells from entering an anergic state or undergoing premature apoptosis.
In murine lymphoid organs and blood, all CD4+ and CD8+ T cells express CD28. In the thymus, CD28 expression is highest on immature CD3-, CD8+, and CD4+8+ cells.
Diseases associated with CD28 dysfunction include mycosis fungoides and Sezary’s Disease.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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