Thermo Fisher Scientific CD28 Monoclonal Antibody (4G3)
인간 CD28 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western Blot 및 ELISA에 적합합니다. PBS 버퍼에 보존제 없이 액상 형태로 제공되며, 친화 크로마토그래피로 정제되었습니다. T 세포 활성화 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G3 |
| Immunogen | CD28 (NP_006130.1, 18–152 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GNKILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKP
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein.
It is a cell adhesion molecule of the immunoglobulin superfamily, constitutively expressed on most peripheral blood T lymphocytes.
CD28 provides a critical co-stimulatory signal by binding CD80 and CD86 on antigen-presenting cells, preventing T cells from entering anergic or apoptotic states.
In murine lymphoid organs, all CD4+ and CD8+ T cells express CD28, with expression highest on immature thymocytes.
Diseases associated with CD28 dysfunction include mycosis fungoides and Sezary’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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