Thermo Fisher Scientific CD28 Monoclonal Antibody (8D7)
Thermo Fisher Scientific CD28 Monoclonal Antibody (8D7)은 인간 CD28 단백질을 인식하는 Mouse IgG1 항체로, WB 및 ELISA에 사용됩니다. Affinity chromatography로 정제되었으며 PBS buffer에 보존제 없이 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 8D7 |
| Immunogen | CD28 (NP_006130.1, 18–152 a.a.) partial recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
GNKILVKQSP MLVAYDNAVN LSCKYSYNLF SREFRASLHK GLDSAVEVCV VYGNYSQQLQ VYSKTGFNCD GKLGNESVTF YLQNLYVNQT DIYFCKIEVM YPPPYLDNEK SNGTIIHVKG KHLCPSPLFP GPSKP
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein.
It is a cell adhesion molecule of the immunoglobulin superfamily constitutively expressed on most peripheral blood T lymphocytes. CD28 provides the critical costimulatory signal by binding CD80 and CD86 on antigen-presenting cells, preventing T cells from entering an anergic or apoptotic state.
In murine peripheral lymphoid organs, all CD4+ and CD8+ T cells express CD28. Expression is highest on immature thymocytes (CD3-, CD8+, CD4+8+, and CD4-8- alpha/beta and gamma/delta TCR+ cells).
Diseases associated with CD28 dysfunction include mycosis fungoides and Sezary’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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