Thermo Fisher Scientific PKA alpha Monoclonal Antibody (6D2.1)
인간 PKA α 촉매 서브유닛을 인식하는 Mouse IgG1 단클론 항체로, Western blot 및 Dot blot에 적합. 1 mg/mL 농도의 액상 형태이며 Protein A로 정제됨. PBS(pH 7.4) 버퍼에 sodium azide 포함, 4°C 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
- Publications: -
Dot Blot (DB)
- Tested Dilution: Assay-dependent
- Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6D2.1 |
| Immunogen | Synthetic peptide corresponding to residues ESPAQNTAHLDQFERIK of human protein kinase Ac alpha (PKAc alpha) (aa 32–49) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, do not freeze |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1090646 |
Product Specific Information
This antibody reacts with human protein kinase A (PKA) catalytic (PKAc) alpha subunit and weakly with PKAc gamma subunit (both ~40 kDa).
The recognized epitope of PKAc alpha is identical among human, sheep, pig, ox, and dog.
Target Information
Protein kinase A (PKA, cAMP-dependent protein kinase) is a key component in cellular signaling related to the cell cycle, communication, memory formation, and behavior.
PKA consists of two catalytic (PKAc) and two regulatory (PKAr) subunits. Upon cAMP binding, the complex dissociates into a PKAr dimer and two activated PKAc monomers.
Activated PKAc can translocate into the nucleus to regulate nuclear hormone receptor activation. PKAc-mediated activation of tonicity-dependent gene expression occurs independently of cAMP.
Humans express three PKAc subunits: alpha (ubiquitous), beta, and gamma (testis-specific).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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