Thermo Fisher Scientific CD86 Monoclonal Antibody (BU63), PE-Cyanine7
인간 CD86 단백질을 인식하는 mouse IgG1 단클론 항체로, PE-Cyanine7 형광 표지된 제품입니다. Flow Cytometry에 최적화되어 있으며, 항원제시세포의 CD86 발현 분석에 사용됩니다. 액상 형태로 4°C 보관, 연구용 전용입니다.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 4 µL/10^6 cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BU63 |
| Immunogen | B-lymphoblastoid cell line ARH 77 |
| Conjugate | PE-Cyanine7 |
| Excitation / Emission Max | 569 / 780 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898667 |
Additional Formats
- Unconjugated
- APC
- FITC
- PE
- PE-Cyanine5
- PerCP
- Custom conjugation available
Product Specific Information
This antibody reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of the immunoglobulin supergene family, expressed on professional antigen-presenting cells such as dendritic cells, macrophages, or activated B lymphocytes.
Target Information
CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation. Insufficient co-stimulation involving CD86/CD80 can induce tolerance. CD86 is a type I membrane protein of the immunoglobulin superfamily, expressed by antigen-presenting cells, and serves as a ligand for CD28 and CTLA4 on T cells. Binding to CD28 provides activation signals, while binding to CTLA4 negatively regulates T-cell activation. Alternative splicing produces multiple transcript variants. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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