Thermo Fisher Scientific CD86 Monoclonal Antibody (BU63), PE-Cyanine7

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 4 µL/10^6 cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• PE-Cyanine5
• PerCP
• Custom conjugation available

Product Specific Information

This antibody reacts with an extracellular epitope of CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of the immunoglobulin supergene family, expressed on professional antigen-presenting cells such as dendritic cells, macrophages, or activated B lymphocytes.

Target Information

CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. It acts as a costimulatory molecule in eliciting T-cell help during antigen presentation. Insufficient co-stimulation involving CD86/CD80 can induce tolerance. CD86 is a type I membrane protein of the immunoglobulin superfamily, expressed by antigen-presenting cells, and serves as a ligand for CD28 and CTLA4 on T cells. Binding to CD28 provides activation signals, while binding to CTLA4 negatively regulates T-cell activation. Alternative splicing produces multiple transcript variants. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지