Thermo Fisher Scientific Sclerostin Polyclonal Antibody
Thermo Fisher Scientific의 Sclerostin Polyclonal Antibody는 마우스 단백질 SOST/Sclerostin을 인식하는 고순도 항체로, WB 및 IHC(F) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS와 trehalose로 안정화되어 장기 보관이 가능합니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Frozen) (IHC (F)) | 5–15 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse SOST/Sclerostin (Gln24–Tyr211) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2605802 |
Product Specific Information
- In direct ELISAs, less than 2% cross-reactivity with recombinant human SOST is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Sclerostin is a glycoprotein predominantly secreted by osteocytes and belongs to the Cerberus/DAN family of BMP antagonists. It functions as an endogenous regulator of the canonical Wnt signaling pathway and bone homeostasis. Although mainly expressed by osteocytes, sclerostin is also found in bone, bone marrow, cartilage, kidney, and liver, and is produced by hypertrophic chondrocytes and cementocytes.
Sclerostin regulates the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LRP5 and LRP6, essential co-receptors for Wnt ligands. It also interacts with LRP4 to inhibit Wnt signaling and promotes osteoclast activity by increasing RANKL expression in osteocytes. Mutations causing reduced sclerostin expression lead to bone dysplasia disorders such as sclerosteosis and van Buchem disease, characterized by excessive bone growth and hypermineralization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-46977_Sclerostin_Q99P68-1_Goat.svg, PA5-46977_Sclerostin_Q99P68-1_Goat_PDP.jpeg)
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