Thermo Fisher Scientific Phospho-Cytokeratin 18 (Tyr13) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Antibody detects endogenous levels of Cytokeratin 18 only when phosphorylated at Tyr13.

Target Information

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8.
It is expressed in tissues from the gastrointestinal, respiratory, and urogenital tracts, as well as in endocrine, exocrine, and mesothelial cells.
Cytokeratin 18 is mainly found in non-squamous epithelia and is present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas.
Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis.
Two transcript variants encoding the same protein have been identified.
Cytokeratin subtype expression patterns are increasingly used to distinguish different epithelial malignancies.
Cytokeratin antibodies assist in tumor differential diagnosis via immunohistochemistry, and are also useful in cytopathology and flow cytometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.