Thermo Fisher Scientific Fibronectin Monoclonal Antibody (FN1/3036)
인간 Fibronectin(FN1)을 특이적으로 인식하는 마우스 단클론 항체. IHC, ELISA, Peptide Array 등 다양한 응용에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, PBS(pH 7.4) 버퍼에 보존제 없이 제공. -20°C 보관, 동결/해동 반복은 피할 것.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FN1/3036 |
| Immunogen | Recombinant fragment (around aa 467–595) of human fibronectin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling, and also found as a soluble plasma protein.
Fibronectin consists of repeating modules forming interaction domains with itself, other matrix components (e.g., collagen, heparin), and cell receptors (e.g., integrins). It plays a key role in cell adhesion and migration, including embryogenesis, wound healing, blood coagulation, host defense, and metastasis.
Fibronectin expression increases notably in non-small cell lung carcinoma, enhancing tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents. The FN1 gene undergoes alternative splicing, generating up to 20 transcript variants, though not all full-length forms have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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