Thermo Fisher Scientific Fibronectin Monoclonal Antibody (FN1/3036)

Applications and Tested Dilutions

Product Specifications

Target Information

Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is most abundant during embryonic development and tissue remodeling and also exists as a soluble plasma protein.

Fibronectin consists of repeating modules forming domains that interact with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell surface receptors (e.g., integrins). It plays key roles in cell adhesion and migration processes such as embryogenesis, wound healing, blood coagulation, host defense, and metastasis.

Fibronectin expression is elevated in non-small cell lung carcinoma, where its interaction with cancer cells enhances tumorigenicity and resistance to apoptosis. The fibronectin gene undergoes alternative splicing, potentially generating up to 20 transcript variants, though not all have been fully characterized.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.