Thermo Fisher Scientific Fibronectin Monoclonal Antibody (FN1/2950)
인간 Fibronectin 단백질을 인식하는 마우스 단클론 항체로, IHC, ELISA 등 다양한 면역분석에 적합합니다. 단백질 A/G로 정제된 액상 항체이며, 보존제 없이 PBS(pH 7.4)에 용해되어 있습니다. -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | FN1/2950 |
| Immunogen | Recombinant fragment (around aa 467–595) of human fibronectin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
Target Information
Fibronectin is a disulfide-bonded dimer with a molecular weight range of 230–250 kDa. In the extracellular matrix of connective tissues and vessels, fibronectin exists as an insoluble, cross-linked protein forming high molecular mass polymers. It is abundant during embryonic development and tissue remodeling and also found as a soluble plasma protein.
Fibronectin consists of repeating modules forming domains that interact with fibronectin itself, other matrix components (e.g., collagen, heparin), and cell surface receptors such as integrins. It plays key roles in cell adhesion, migration, wound healing, blood coagulation, and metastasis. Elevated fibronectin expression has been associated with non-small cell lung carcinoma, where it enhances tumorigenicity and resistance to apoptosis induced by chemotherapeutic agents.
The fibronectin gene undergoes alternative splicing, potentially generating up to 20 transcript variants, though the full-length nature of some variants remains undetermined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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