Thermo Fisher Scientific NCAM1 Monoclonal Antibody (OTI2B9), TrueMAB
인간 NCAM1(CD56)을 인식하는 Mouse IgG1 단일클론 항체로, WB와 IHC(P)에서 검증됨. 무보존제, 동결건조 형태이며 1 mg/mL 농도. 신경세포 접착분자 연구 및 신경내분비 종양 표지에 적합.
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Thermo Fisher Scientific NCAM1 Monoclonal Antibody (OTI2B9), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20–718 of human NCAM1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that functions as an adhesive molecule. It is widely expressed in the nervous system with isoforms ranging from 120–180 kDa.
CD56 is present on T cells and NK cells and plays roles in cell migration, axonal growth, pathfinding, and synaptic plasticity. Polysialic modification reduces CD56-mediated adhesion.
Through its extracellular domain, CD56 mediates homophilic and heterophilic interactions with extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and tumors including retinoblastoma, medulloblastoma, astrocytoma, and neuroblastoma. It is also a sensitive neuroendocrine marker for neuroendocrine and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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