Thermo Fisher Scientific TLK2 Monoclonal Antibody (OTI3F2), TrueMAB

Thermo Fisher Scientific TLK2 Monoclonal Antibody (OTI3F2), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

TLK2 (Tousled-like kinase 2) is a nuclear serine/threonine kinase involved in chromatin assembly regulation and other cellular processes such as intracellular signaling, protein phosphorylation, cell cycle control, and DNA damage response.
TLK2 activity peaks during S phase and is regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication leads to rapid loss of TLK2 activity, indicating its tight linkage to replication. TLK2 is inactivated by phosphorylation at Ser-750, potentially by CHK1, and forms heterodimers with TLK1.
This nuclear protein is widely expressed in fetal and adult tissues, including placenta, liver, kidney, pancreas, heart, skeletal muscle, and various cell lines.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.