Thermo Fisher Scientific TLK2 Monoclonal Antibody (OTI3F2), TrueMAB
인간 TLK2 단백질을 인식하는 마우스 단클론 항체로 Western blot 및 IHC에 적합합니다. 무보존제, 동결건조 형태로 제공되며 재구성 후 1 mg/mL 농도로 사용 가능합니다. 크로마틴 조절 및 세포주기 연구에 활용됩니다.
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- CF805462
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- pk
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Thermo Fisher Scientific TLK2 Monoclonal Antibody (OTI3F2), TrueMAB
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3F2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–296 of human TLK2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TLK2 (Tousled-like kinase 2) is a nuclear serine/threonine kinase involved in chromatin assembly regulation and other cellular processes such as intracellular signaling, protein phosphorylation, cell cycle control, and DNA damage response.
TLK2 activity peaks during S phase and is regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication leads to rapid loss of TLK2 activity, indicating its tight linkage to replication. TLK2 is inactivated by phosphorylation at Ser-750, potentially by CHK1, and forms heterodimers with TLK1.
This nuclear protein is widely expressed in fetal and adult tissues, including placenta, liver, kidney, pancreas, heart, skeletal muscle, and various cell lines.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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