Thermo Fisher Scientific PGR Monoclonal Antibody (OTI26C2), TrueMAB
인간 프로게스테론 수용체(PGR)를 인식하는 마우스 단클론 항체로, WB 및 IHC(P)에서 검증됨. 비결합형 동결건조 형태로 제공되며, 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
- 카탈로그번호
- CF805465
- 판매단위
- pk
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI26C2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–298 of human PGR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The progesterone receptor (PR) is a nuclear receptor that mediates the physiological effects of progesterone, essential for reproductive processes such as pregnancy establishment and maintenance.
PR exists as two forms: PR-A (94 kDa) and PR-B (120 kDa), differing by a 165 amino acid deletion at the N-terminus of PR-A.
PR-B is transcriptionally active, regulating genes for endometrial maintenance, pregnancy, and ovulation inhibition.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, conformational changes enable dimerization and DNA binding to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene causes reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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