Thermo Fisher Scientific K-Ras Recombinant Rabbit Monoclonal Antibody (11H35L14)

Applications

Western Blot (WB)

• Tested Dilution: 1:5,000
• View 2 publications

Immunocytochemistry (ICC/IF)

• Tested Dilution: -
• View 1 publication

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Pig, and Rat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning the specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

K-RAS (GTPase KRas) belongs to the Ras oncogene family. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
It plays an important role in regulating cell proliferation and promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes in colorectal cancer cells in a ZNF304-dependent manner.
Mutations in the gene can result in:

• Leukemia (acute myelogenous, juvenile myelomonocytic)
• Noonan Syndrome
• Gastric cancer
• Cardiofaciocutaneous syndrome 2

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)