Thermo Fisher Scientific ZEB1 Recombinant Rabbit Monoclonal Antibody (13H12L8)
ZEB1 단백질을 인식하는 재조합 토끼 단클론 항체로, 높은 특이성과 재현성을 제공합니다. 인간에 반응하며 원숭이, 고양이, 개에서도 예측 반응됩니다. ICC/IF에 적합하며, 단백질 A로 정제된 0.5 mg/mL 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 13H12L8 |
| Immunogen | Peptides corresponding to human ZEB1 (aa58–76, aa1110–1124) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2784576 |
Product Specific Information
This antibody is predicted to react with Monkey, Cat, and Dog.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed to produce specific antibodies. These antibodies offer:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1) is a transcriptional repressor that inhibits interleukin-2 (IL-2) gene expression. It can enhance or repress the promoter activity of the ATP1A1 gene depending on cDNA quantity and cell type. ZEB1 represses E-cadherin promoters and induces epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. It also represses BCL6 transcription in the presence of CTBP1 and regulates neuronal differentiation by repressing RCOR1 activation during neurogenesis. Mutations in ZEB1 can lead to corneal dystrophies such as posterior polymorphous and Fuchs endothelial dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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