Thermo Fisher Scientific CEA Monoclonal Antibody (CB30)
CEA 단백질을 인식하는 마우스 단클론 항체(CB30)로, 인간 시료에 반응합니다. Western blot, IHC, Flow cytometry 등 다양한 응용에 적합합니다. Protein A로 정제된 액상 항체이며, 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 10 µg/mL (1:100) | - |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | Assay-dependent | View 1 publication |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CB30 |
| Immunogen | Human carcinoembryonic antigen (CEA; CEACAM5) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1073298 |
Product Specific Information
This antibody recognizes CD66e (CEA; 180–200 kDa), an extracellular cell surface-bound carcinoembryonic antigen mainly expressed on epithelial cells.
Target Information
CEA (Carcinoembryonic Antigen, CD66e) is synthesized during fetal gut development and re-expressed in intestinal carcinomas and other tumors. It belongs to the immunoglobulin supergene family and consists of one N domain and six immunoglobulin constant-like A (A1, A2, A3) and B (B1, B2, B3) domains.
Antibodies to CEA are valuable for identifying the origin of metastatic adenocarcinomas and distinguishing pulmonary adenocarcinomas (60–70% CEA+) from pleural mesotheliomas (rarely or weakly CEA+).
CEA functions as a cell adhesion molecule and is involved in tissue differentiation, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation. Multiple transcript variants have been reported, though not all are fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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