Thermo Fisher Scientific HLA-DR Monoclonal Antibody (MEM-12)
인간 HLA-DR 단백질을 인식하는 Mouse IgG1 단클론 항체로, Western blot, Flow cytometry, Immunoprecipitation에 사용 가능. 비결합(Unconjugated) 형태로 제공되며, PBS(pH 7.4) 내 15mM sodium azide 포함. 4°C 보관, 단백질 A로 정제됨.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Flow Cytometry (Flow) | 2 µg/mL | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-12 |
| Immunogen | Thymocyte membrane |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1076819 |
Additional Formats Available
Product Specific Information
This antibody recognizes a common extracellular epitope on human HLA-DR that depends on the association of alpha and beta chains.
HLA-DR is a human MHC Class II isotype expressed on antigen-presenting cells (APC) such as dendritic cells, B lymphocytes, monocytes, and macrophages.
Recommended conditions:
- Immunoprecipitation and Western Blot: Non-reducing conditions.
Target Information
HLA-DR is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and a 27 kDa beta chain (DRB).
The alpha chain gene (DRA) contains 5 exons:
- Exon 1: leader peptide
- Exons 2–3: extracellular domains
- Exon 4: transmembrane domain and cytoplasmic tail
DRA acts as the sole alpha chain for DRB1, DRB3, DRB4, and DRB5, while DRB1 contains polymorphisms determining peptide binding specificity.
HLA-DR is expressed primarily on antigen-presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells, and activated T lymphocytes.
HLA and MHC antibodies are important tools in Immunopeptidomics, enabling the identification and characterization of neoantigens through LC-MS/MS analysis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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